CBI’s 20th Annual Medicaid and Government Pricing Congress

CBI’s 20th Annual Medicaid and Government Pricing Congress May 21-23, 2018 | Orlando, FL www.cbinet.com/medicaid Join the Government Pricing industry for YEAR 20 of CBI’s Medicaid Congress at Disney’s Yacht & Beach Club in Orlando! Take a deep dive into sessions on 340B expansion, state pricing and transparency, FSS contracting, value-based frameworks, reasonable assumptions, Medicare coverage and more. You can read all about it here. Visit www.cbinet.com/medicaid for further details and to register. Drug Channels readers will save $300 off the standard rate when they use discount code BMK348 and register prior to April 27th. Features for 2018 Include: Three … Continue reading CBI’s 20th Annual Medicaid and Government Pricing Congress

Connect With Drug Channels at #Asembia18

In three weeks, Drug Channels Institute will hit Las Vegas for Asembia’s 2018 Specialty Pharmacy Summit. Here are three ways that you can interact with us in Las Vegas: 1) Learn how Drug Channels can help your business. Drug Channels reaches a large, diverse audience throughout the pharmaceutical and healthcare industries. We have an engaged and growing audience of more than 21,000 readers who regularly open, click, forward, and share our content. Drug Channels has an engagement rate that is more than twice that of the average media platform. To discover how you can reach our audience, you can speak … Continue reading Connect With Drug Channels at #Asembia18

Payer Power: Why Eli Lilly, Janssen, and Merck Deeply Discount Their Drug Prices

Over the past few weeks, three of the largest pharmaceutical manufacturers—Eli Lilly, Janssen, and Merck—have publicly reported the 2017 gross and net price changes for their U.S. product portfolios, along with average discounts. As far as I know, these are the only manufacturers that have publicly reported these data. See the links below. As you will see, the three companies have provided average discounts from list prices of 42% to 51%. Two of the three companies experienced a year-over-year decrease in average net prices. Payers and PBMs frequently recommend that manufacturers just lower the cost of their drugs. These data … Continue reading Payer Power: Why Eli Lilly, Janssen, and Merck Deeply Discount Their Drug Prices

The Mysteries of Pass-Through Status: Why Medicare and Seniors Are Now Paying More for Lower-Cost Biosimilars at Hospitals

An unanticipated combination of government policy changes has led to a truly bizarre circumstance: The Medicare program and individual Medicare patients are paying more for lower-cost biosimilars. Further, hospitals are earning windfall profits from these lower-cost biosimilars, though physician offices can’t access the same financial benefits. Sound bonkers? You bet. To understand this strange turn of events, I delve into the vagaries of Medicare Part B reimbursement and the recently implemented outpatient prospective payment system (OPPS) rule for drugs acquired under the 340B Drug Pricing Program. As I explain below, the Centers for Medicare & Medicaid Services (CMS) recently made … Continue reading The Mysteries of Pass-Through Status: Why Medicare and Seniors Are Now Paying More for Lower-Cost Biosimilars at Hospitals

Data Rev18 Summit

Data Rev18 Summit June 19-20 | Philadelphia, PA www.worldcongress.com/events/DataCongress This June 19 – 20 Philadelphia will become home to three case study driven events under 1 roof focused on real world data. Over 150+ data leaders will convene at the Data Rev18 Summit in Philadelphia. Attend the only Congress aiming to break down the organizational silos in order to facilitate a seamless and free flow movement of data, throughout the life cycle from Clinical all the way through Commercial – aiding your business in truly embracing Data Driven Decision Making. Register with discount code DC200 and save $200 off of … Continue reading Data Rev18 Summit

LMS Administrator Hiring – What you need to know to find the right 1

Back in the 90’s (I think), there was “Where’s Waldo” books and stuff like that.  Find “Waldo” was the rage. He was this dorky looking guy with a striped sock on his head (ok, it was a long knit hat) and you had to look for him on each page with lots of other folks on it too.  I always wondered how awesome it would be to have a page where he isn’t anywhere on the page, and have readers constantly looking for him.  Ha, that would have rocked. The funky thing about Waldo was on each book page, there … Continue reading LMS Administrator Hiring – What you need to know to find the right 1

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses. Phosphorylation converts eIF2 from a substrate to a competitive inhibitor of its dedicated guanine nucleotide exchange factor, eIF2B, thereby inhibiting translation. ISRIB, a drug-like eIF2B activator, reverses the effects of eIF2 phosphorylation, and in rodents it enhances cognition and corrects cognitive deficits after brain injury. To determine its mechanism of action, we solved an atomic-resolution structure of ISRIB bound in a deep cleft within decameric human eIF2B by cryo–electron microscopy. Formation of fully active, decameric eIF2B holoenzyme … Continue reading Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule