CVS Health: Will This Giant’s Scale and Scope Confound Its Vision for Healthcare?

Last week, CVS Health held its annual investor day. (Links below.) In the aftermath of the Aetna transaction, CVS Health has become a uniquely diverse organization with revenues exceeding $250 billion. As expected, CVS Health management explained the cost-cutting synergies that it expects from having united CVS Health and Aetna. It also laid out a long-range vision for generating value—and operating income—from making the disparate pieces of its empire work together in new ways. CVS Health called these new products and services “transformational initiatives.” Below, I summarize investor day high points concerning CVS Health’s overall strategy, offer thoughts on the … Continue reading CVS Health: Will This Giant’s Scale and Scope Confound Its Vision for Healthcare?

CBI’s Reimbursement and Access 2019

Reimbursement and Access 2019 August 13-14, 2019 DoubleTree by Hilton Center City | Philadelphia, PA www.cbinet.com/Reimbursement CBI’s Reimbursement and Access conference returns for the 7th year and takes place August 13-14, 2019 in Philadelphia, PA. This event arms attendees with real-time policy briefings, impactful managed market trends and strategies to ensure product access. Drug Channels readers: use discount code QEF679 and save $500* off the standard rate when you register by July 19, 2019. Below is a first look at the robust lineup of esteemed thought-leaders driving this year’s dialogue. Christina Sandefur, Executive Vice President, Goldwater Institute Jeff Henderson, Vice … Continue reading CBI’s Reimbursement and Access 2019

New Strategies Sought to Pay for Costly Cures

As Congressional leaders and White House policymakers assess a range of measures designed to manage or reduce outlays for prescription drugs, pharma companies and other stakeholders are weighing innovative reimbursement models for new therapies promising to cure or treat serious illnesses. Payer Powered by WPeMatico Continue reading New Strategies Sought to Pay for Costly Cures

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 normal tissues revealed multiple somatic variants, demonstrating that macroscopic clones can be found in many normal tissues. We found that sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests that environmental factors can promote somatic mosaicism. Mutation burden was associated with both age and tissue-specific cell proliferation rate, highlighting that mutations accumulate over both time and number of cell divisions. Finally, normal tissues were found to harbor mutations in known cancer … Continue reading RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Profits in the 2019 Fortune 500: Manufacturers vs. Managed Care vs. Pharmacies, PBMs, and Wholesalers

Time to dive into our 12th (!) annual review of the Fortune 500 list. Every year, this is one of my most popular posts, because it helps us follow the dollar and understand how drug channel intermediaries make money. Fortune’s 2019 list contains only six drug channel companies: AmerisourceBergen, Cardinal Health, CVS Health, McKesson, Rite Aid, and Walgreens Boots Alliance. Consolidation and vertical integration have transformed the channel—and the Fortune rankings. Below you will see our list of the companies that disappeared from the roster. We therefore have added to our analysis the four managed care and insurance companies on … Continue reading Profits in the 2019 Fortune 500: Manufacturers vs. Managed Care vs. Pharmacies, PBMs, and Wholesalers

Medicaid Drug Rebate Program Summit 2019

Medicaid Drug Rebate Program Summit 2019 September 23-25, 2019 Renaissance Chicago Downtown | Downtown Chicago, IL Join KNect365 for the 24th year of MDRP this September 23-25, 2019 at the Renaissance Chicago Downtown in Downtown Chicago, IL. This is your opportunity to benchmark best practices and gain solutions to overcome new operational challenges brought on by AMP Final Rule, 340B, Medicare Part B, Medicare Part D coverage gap, FSS, VA, OIG, and other critical government programs. See why this is an event you can’t afford to miss! Register Now and use Priority Code P19MDRPDRUG to SAVE an additional $200 off … Continue reading Medicaid Drug Rebate Program Summit 2019

Insular cortex processes aversive somatosensory information and is crucial for threat learning

Learning about threats is essential for survival. During threat learning, an innocuous sensory percept such as a tone acquires an emotional meaning when paired with an aversive stimulus such as a mild footshock. The amygdala is critical for threat memory formation, but little is known about upstream brain areas that process aversive somatosensory information. Using optogenetic techniques in mice, we found that silencing of the posterior insula during footshock reduced acute fear behavior and impaired 1-day threat memory. Insular cortex neurons respond to footshocks, acquire responses to tones during threat learning, and project to distinct amygdala divisions to drive acute … Continue reading Insular cortex processes aversive somatosensory information and is crucial for threat learning